The Dry Eye Zone

Rebecca's Blog


Study: Symptom improvements and treatment reductions with autologous serum tear use

I wish they had included OSDI in this study. The heterogeneity of outcomes measures in dry eye studies is incredibly annoying. On the other hand, I always feel bound to be grateful at the inclusion of ANY symptom measures, and SANDE and DEQ-5 are widely accepted.

The other thing that is really annoying me about serum studies lately is no mention of concentration in the abstract.

However, I’m glad for any addition to the literature on this. I like the fact that people using serum drops apparently used fewer total treatments, and that their symptoms scores dropped by so much.

Patient-reported outcomes of autologous serum tears for the treatment of dry eye disease in a large cohort. Kreimei M et al, Ocul Surf. 2019 Jul 2. pii: S1542-0124(19)30080-1.


To assess patient satisfaction with autologous serum tears (AST) for the treatment of dry eye disease (DED).


A prospective, observational case-series, including 100 participants who were treated with AST for DED. The five-item Dry Eye Questionnaire (DEQ-5), Symptom Assessment in Dry Eye (SANDE) Questionnaire, and the Treatment Satisfaction Questionnaire for Medication (TSQM) were used to assess DED symptoms and patients' treatment satisfaction.


The duration of AST treatment was 1-6 months in 25%, 6-12 months in 24%, 1-2 years in 22%, and 2-3 years in 29% of the participants. The mean cumulative DEQ-5 score was 12.7 ± 3.8 and 65% of the participants scored ≥12, which may suggest an underlying diagnosis of Sjögren's syndrome. The use of other treatments was significantly reduced after the use of AST (P < 0.001). The mean total SANDE score improved from 79.5 ± 21.8, 95% CI [75.2, 83.8] before to 42.2 ± 23.2, 95% CI [37.6, 46.8] after using AST (P < 0.001). The mean TSQM treatment efficacy, convenience, and global satisfaction scores were 73.1 ± 17.2, 95% CI [69.6, 76.5], 72.5 ± 17.5, 95% CI [69.0, 76.0], and 74.6 ± 22.7, 95% CI [70.1, 79.0]. No patients reported any side effects.


Autologous serum tears treatment in severe dry eye disease significantly reduced dry eye symptoms, with high patients' satisfaction scores.