The Dry Eye Zone

Rebecca's Blog

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Study: Dry eye surface damage worse in long term type 2 diabetes

We don't tend to get a lot of discussion about dry eye and diabetes, so I thought I would highlight one of the dry eye studies on this. It comes up occasionally in conversations I have with patients, if it's been flagged by their doctor as a possible exacerbating factor.

J Ophthalmol. 2018 Jul 15;2018:1206808. doi: 10.1155/2018/1206808. eCollection 2018.
Assessment of Ocular Surface Damage during the Course of Type 2 Diabetes Mellitus.
He F, Zhao Z, Liu Y, Lu L, Fu Y.

Abstract
PURPOSE:
To investigate the impact of disease duration on the ocular surface during the course of type 2 diabetes mellitus compared with nondiabetic controls.

METHODS:
One hundred twenty diabetic patients were divided into three groups according to disease duration: less than 5 years, 5-10 years, and over 10 years. All eyes were imaged using a corneal topographer (Oculus Keratograph 5M). Tear film measurements and meibography were also recorded. Meibomian gland changes were scored from 0 to 6 (meiboscore).

RESULTS:
The noninvasive breakup time first (NIKBUT-1st) and noninvasive breakup time average (NIKBUT-avg) were significantly shorter in the over 10 years diabetic group compared with the control group (P=0.0056  and  P=0.010, resp.). Tear meniscus height (TMH) was significantly lower in the over 10 years diabetic group compared with the control group (P=0.0016) and the 5 years group (P=0.0061). We also found that more patients in the over 10 years diabetic group showed bulbar and limbal hyperemia compared with the control group (bulbar hyperemia: P=0.049; limbal hyperemia: P=0.026). The meiboscore in the over 10 years diabetic group was significantly higher compared with the other three groups (P < 0.05). Bulbar hyperemia showed a significant negative correlation with NIKBUT-1st in the over 10 years diabetic group (r=-0.35  and  P < 0.05).

CONCLUSION:
Ocular surface damage in long-term type 2 diabetes is more severe than that in patients with shorter disease duration.