The Dry Eye Zone

Rebecca's Blog


Abstract: Sex hormone therapy in dry eye treatment (meta-analysis)

This study analyzed data from 27 years worth of studies… which sounds ever so impressive until you notice that they were only able to use 7 studies with a total of 358 patients. Heterogeneity of study methods strikes again! It will be very nice when, Some Day, we can compare studies apples to apples.

Anyway, for what it’s worth, this study found that sex hormone therapy improved Schirmer scoes but did not improve tear break-up time or ocular comfort index.

Medicine (Baltimore). 2018 Oct;97(40):e12572. doi: 10.1097/MD.0000000000012572.

Sex hormone therapy's effect on dry eye syndrome in postmenopausal women: A meta-analysis of randomized controlled trials.

Liu C, Liang K, Jiang Z, Tao L.


THE PURPOSE OF THE STUDY T: o assess the efficacy of sex hormone therapy in the treatment of dry eye syndrome in postmenopausal women.The following electronic databases were searched without language restrictions: PubMed, Embase, Cochrane, and the Chinese Biomedical Database. Two reviewers collected all the literature, which was searched for relevance in English and Chinese from January 1990 to July 2017. Both of the reviewers screened documents independently, identifying the studies that met the inclusion criteria. Then, the included studies were evaluated, and the data were extracted and conversed dependently. Finally, Review Manager 5.3 (offered by the Cochrane collaboration) was used to complete the meta-analysis. An integrated mean difference (MD) with its corresponding 95% confidence interval (CI) was calculated.A total of 358 patients with dry eye were enrolled in 7 randomized controlled trials (RCTs). We observed statistically significant improvements in the Schirmer's test scores (MD, 2.06; 95% CI, 0.74-4.46; I = 97%; P = .006) after sex hormone treatment. However, the scores for tear breakup time (TBUT) (MD, 1.28; 95% CI, -1.03 to 4.68; I = 99%; P = .21) and the ocular comfort index (OCI) (MD, -1.12; 95% CI, -4.42 to 1.98; I = 95%; P = .48) were not improved.This meta-analysis of 7 RCTs suggests that sex hormone therapy may be associated with better Schirmer's test scores. However, no significant differences were detected in the TBUT and OCI test scores. Consequently, sex hormone therapy has a potentially useful role in the effective management of postmenopausal women with dry eye syndrome.