The Dry Eye Zone

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Abstract: Corneal neuropathic pain and blepharospasm

I really appreciate starting to see things in the pain journals on this topic.

Chronic (neuropathic) corneal pain and blepharospasm: Five case reports.

Pain and focal dystonias have been associated with chronic pain conditions such as complex regional pain syndrome. Corneal pain, frequently known as "dry eye", may be a neuropathic pain condition with abnormalities of the nerve plexus. Here we present 5 case histories of patients with defined corneal pain (with associated neuropathic features) and objective measures of changes in the nerve plexus and associated blepharospasm. A putative relationship between pain and blepharospasm suggests potential involvement of the basal ganglia in both these conditions.


Pain. 2011 Oct;152(10):2427-31. Epub 2011 Jul 12.
Borsook D, Rosenthal P.
Source
Center for Pain and the Brain, McLean Hospital, Massachusetts General Hospital, and Children's Hospital of Boston, Harvard Medical School, Boston, MA, USA.
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