The Dry Eye Zone

Rebecca's Blog


Abstract: SPHP700-3 (OTC drop)

Don't get excited yet. It's apparently a povidone OTC drop "showed to be safe and effective in mild to moderate dry eye". The same could probably be said of any OTC lubricant drop... No information available yet to tell us what if anything is different here.

A Multicenter, Double-Blind, Parallel Group, Placebo-Controlled Clinical Study to Examine the Safety and Efficacy of T-Clair SPHP700-3 in the Management of Mild to Moderate Dry Eye in Adults.
Cornea. 2010 Nov 17. [Epub ahead of print]
Villani E, Laganovska G, Viola F, Pirondini C, Baumane K, Radecka L, Ratiglia R.

From the *UO Oculistica, Dipartimento di Neuroscienze e Organi di Senso, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Universitá degli Studi di Milano, Milan, Italy; and †Department of Ophthalmology, Stradins University Hospital, Riga, Latvia.

PURPOSE: To study the safety and efficacy of T-Clair SPHP700-3, a new over-the-counter preservative-free formulation, in the management of mild to moderate dry eye in adults.

METHODS: Sixty adult patients with mild to moderate dry eye were consecutively recruited in 2 eye clinics and randomized into 2 groups: treatment and placebo. Signs and symptoms of dry eye were compared along 28 days of treatment.

RESULTS: No adverse events were reported during the study. Symptoms and signs of dry eye showed significant differences between the 2 groups after 2 and 4 weeks of treatment.

CONCLUSIONS: SPHP700-3 preservative-free formulation showed to be safe and effective in mild to moderate dry eye, improving tear film stability, ocular surface lubrification, and patients' symptomatology.