The Dry Eye Zone

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Abstract: Using a confocal to diagnose Demodex

In vivo evaluation of Ocular Demodicosis using Laser Scanning Confocal Microscopy.
Invest Ophthalmol Vis Sci. 2010 Sep 16. [Epub ahead of print]
Kojima T, Ishida R, Sato EA, Kawakita T, Ibrahim OM, Matsumoto Y, Kaido M, Dogru M, Tsubota K.
Keio University School of Medicine, J&J Ocular Surface and Visual Optics, Tokyo, Japan.

Purpose:
To investigate the applicability of in vivo laser scanning confocal microscopy in the diagnosis and follow up of ocular demodicosis infestation in a prospective controlled study

Methods:
Fifteen right eyes of 15 patients with blepharitis associated with cylindrical dandruff (10 males, 5 males; mean age: 62.9±9 years) and 8 right eyes of 8 age and sex matched control subjects underwent HRTII/ RCM, evaluation of ocular symptom scores, tear function tests including vital stainings, Schirmer test, tear clearance test and evaluation of mite numbers in the eye lids.
Results:
In vivo confocal microscopy effectively disclosed the mites in the terminal bulbs of the eyelashes which were not observed after treatment. Eyelids with Demodicosis infestation showed marked inflammatory infiltrates around the meibomian glands and conjunctiva which cleared with tea tree oil treatment.

Conclusion:
Laser scanning confocal microscopy seems to be an efficient non-invasive tool in the diagnosis and follow up of ocular demodicosis infestation.
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