Abstract: Systane after cat surgery
The effect of preservative-free HP-Guar on dry eye after phacoemulsification: a flow cytometric study.
Eye (Lond). 2010 Mar 19. [Epub ahead of print]
Sánchez MA, Arriola-Villalobos P, Torralbo-Jiménez P, Girón N, de la Heras B, Herrero Vanrell R, Alvarez-Barrientos A, Benítez-Del-Castillo JM.
Department of Ophthalmology, Hospital Clínico San Carlos, Madrid, Spain.
To assess the effect of hydroxypropyl (HP)-Guar added to regular post-phacoemulsification treatment in dry eye signs and symptoms, and its influence on the expression of various inflammatory markers by flow cytometry (FCM) in impression cytology specimens.
This prospective, interventional, single-centre study included 48 eyes of 48 patients with age-related cataract. After phacoemulsification, patients were randomised to the usual treatment group (UT), with 21 patients who received tobramycin and dexamethasone eye drops (Tobradex, Alcon Cusí, Spain), and the HP-Guar group, with 27 patients who received the UT plus preservative-free artificial tears (Systane UD, Alcon Cusí, Spain). Corneal and conjunctival staining with fluorescein and lissamine green, tear film break-up time (TBUT), Schirmer's I test with anaesthesia (Jones test), tear clearance, and ocular surface disease index (OSDI) were assessed preoperatively and 1 month after surgery. Besides, conjunctival impression cytology was performed in order to investigate inflammatory markers (CD3, CD11b, and HLA-DR) using FCM.
HP-Guar group shows statistical better results compared with the UT group in TBUT (6.4+/-0.7 vs9+/-2.5, P=0.0004), OSDI (11.5+/-8.2 vs3.3+/-2.5, P=0.0002), ocular symptoms subscale (7.3+/-6.1 vs1.7+/-1.8, P=0.0004), vision-related function subscale (2.2+/-1.8 vs0.4+/-0.6, P=0.0002), CD3 (2.5+/-1.4 vs1.1+/-1.1, P=0.011), and HLA-DR (6.8+/-4.5 vs1.8+/-1.7, P=0.0002).
The addition of HP-Guar to regular treatment after cataract surgery reduces ocular surface inflammation and dry eye signs and symptoms.