The Dry Eye Zone

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Abstract: AVR Lid cleanser results

I am not sure whether this is referring to Sterilid or another product under development. I will update this post when I hear back from AVR.

Time-Kill Assay Results for a Linalool-Hinokitiol-Based Eyelid Cleanser for Lid Hygiene.
Cornea. 2010 Mar 18. [Epub ahead of print]
Gilbard JP, Douyon Y, Huson RB.
Jeffrey P. Gilbard, MD February 19, 1954 - August 12, 2009 Dr. Gilbard was best known for his pioneering research that led to treatments for dry eye disease. He also was considered one of the first ophthalmologists and researchers to understand the correlation between nutrition and health of the eye. He was my friend and mentor in the field of ophthalmology. Robert Huson, Advanced Vision Research. From the *Department of Ophthalmology, Harvard Medical School, Boston, MA; and daggerAdvanced Vision Research, Woburn, MA.

PURPOSE:: Time-kill testing was performed for a linalool-hinokitiol-based eyelid cleanser against Pseudomonas aeruginosa, Moraxella catarrhalis, Escherichia coli, Serratia marcescens, Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), Staphylococcus epidermidis, and Pityrosporum ovale to evaluate its efficacy.

METHODS:: An inoculum of 1 mL of each test organism culture was added to 49 mL of test cleanser. At 30 seconds and 1 minute, 1 mL of sample was removed from each test mixture and added to 9 mL of neutralizer. Five milliliters of aliquots were incubated for 48 hour and counted for colony-forming units. Ten percent povidone-iodine was used as a control.

RESULTS:: At 30 seconds, the linalool-hinokitiol-based eyelid cleanser produced a 99.9999% reduction in P. aeruginosa, a 99.999% reduction in E. coli, a 99.99% reduction in M. catarrhalis and S. marcescens, a 99.9% reduction in MRSA, a 99.2% reduction in S. epidermidis, and a 97.5% reduction in S. aureus. At 1 minute, this cleanser achieved a95.8% reduction in P. ovale. At 30 seconds, povidone-iodine produced a 99.9999% reduction in P. aeruginosa and M. catarrhalis, a 99.999% reduction in S. marcescens and a 94.9% reduction in S. epidermidis. At 1 minute, 10% povidone-iodine produced a 93.8% reduction in E coli but failed to produce a 1-log reduction in S. aureus or MRSA.

CONCLUSIONS:: This linalool-hinokitiol-based eyelid cleanser may be helpful in the outpatient setting for patients with presurgical, blepharitis, punctal plug and dry eye, and in the inpatient setting for patients who are allergic to iodine, or as an adjunct to povidone-iodine.
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