The Dry Eye Zone

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Abstract: Liposomal spray

I think this is the product sold in the UK as Eye Logic (formerly Clarymist) and in the US as Tears Again Liposomal Spray.

Effect of a liposomal spray on the pre-ocular tear film.
Cont Lens Anterior Eye. 2010 Jan 20. [Epub ahead of print]
Craig JP, Purslow C, Murphy PJ, Wolffsohn JS.
Department of Ophthalmology, University of Auckland, New Zealand; Ophthalmic Research Group, Aston University, Birmingham, UK.

PURPOSE: With the potential to address evaporative dry eye, a novel spray has been developed in which phospholipid liposomes are delivered to the tear film via the surface of the closed eyelid. This study evaluated the short-term effects of liposomal spray application on the lipid and stability characteristics of the pre-ocular tear film in normal eyes.

METHODS: Twenty-two subjects (12M, 10F) aged 35.1+/-7.1 years participated in this prospective, randomised, double-masked investigation in which the liposomal spray was applied to one eye, and an equal volume of saline spray (control) applied to the contralateral eye. Lipid layer grade (LLG), non-invasive tear film stability (NIBUT) and tear meniscus height (TMH) were evaluated at baseline, and at 30, 60, 90 and 135min post-application. Subjective reports of comfort were also compared.

RESULTS: Treated and control eyes were not significantly different at baseline (p>0.05). Post-application, LLG increased significantly, at 30 and 60min, only in the treated eyes (p=0.005). NIBUT also increased significantly in the treated eyes only (p<0.001), at 30, 60 and 90min. TMH did not alter significantly (p>0.05). Comfort improved relative to baseline in 46% of treated and 18% of control eyes, at 30min post-application. Of those expressing a preference in comfort between the eyes, 68% preferred the liposomal spray.

CONCLUSIONS: Consistent with subjective reports of improved comfort, statistically and clinically significant improvements in lipid layer thickness and tear film stability are observed in normal eyes for >/=1h after a single application of a phospholipid liposomal spray. Crown Copyright © 2010. Published by Elsevier Ltd. All rights reserved.
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