The Dry Eye Zone

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Abstract: Carmellose sodium, sodium hyaluronate

I would love to get some comments on this one from Those Who Know. First off I don't really know anything about the carmellose drop. Secondly, with HLA drops, it's always a little tricky because (as I first learned with Dr. Holly's drops) just the name & concentration don't always tell you what you need to know. What is Lubristil and how does it compare to other HLA drops on the market in Europe and the US?

Comparative Analysis of Carmellose 0.5% Versus Hyaluronate 0.15% in Dry Eye: A Flow Cytometric Study.
Cornea. 2009 Dec 16. [Epub ahead of print]
Sanchez MA, Torralbo-Jimenez P, Giron N, de la Heras B, Herrero Vanrell R, Arriola-Villalobos P, Diaz-Valle D, Alvarez-Barrientos A, Benitez-Del-Castillo JM.

PURPOSE:: To compare the effects of Viscofresh 0.5% (carmellose sodium 0. 5%) versus Lubristil (sodium hyaluronate 0.15%) in dry eye syndrome and to study the influence of these two treatments on the expression of various inflammatory markers by flow cytometry in impression cytology specimens.

METHODS:: In this randomized, masked-observer, parallel group, single-center study, 15 patients with dry eye syndrome were randomized to sodium carmellose 0.5% or sodium hyaluronate 0.15% 1-month treatment after a 1-week washout period. Corneal staining with flurescein, breakup time, Schirmer 1 test with anesthesia (Jones test), and tear clearance were assessed. Besides, conjunctival impression cytology was performed to investigate inflammatory markers (CD3, CD11b, and HLA-DR) using flow cytometry.

RESULTS:: Carmellose group shows statistical improvement compared with the hyaluronate group in breakup time, corneal staining, and HLA-DR. The two other inflammatory markers had also a tendency for a decreased expression in both groups, with no statistical significance. There were neither visual acuity loss nor other complications related to treatment.

CONCLUSION:: Both artificial tears improve dry eye signs and symptoms and inflammatory markers expression, with significant better results in carmellose group.
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