The Dry Eye Zone

Rebecca's Blog


Abstract: AMT in SJS and TEN

Hm, perhaps we need a few more acronyms?

I am not a big fan of AMT in more common dry eye cases because I've so rarely heard from anyone who has been helped by it but in these severe cases I am so glad it's available. I hope that where people sclerals are also being tried on patients in such serious danger of sight-threatening dryness.

Amniotic Membrane Transplantation as a New Therapy for the Acute Ocular Manifestations of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.
Surv Ophthalmol. 2009 Aug 20. [Epub ahead of print]
Shay E, Kheirkhah A, Liang L, Sheha H, Gregory DG, Tseng SC.
TissueTech Inc., Miami, Florida, USA.

Stevens-Johnson syndrome and its more severe variant, toxic epidermal necrolysis, have relatively low overall incidence; however, this disease presents with high morbidity and mortality. The majority of patients develop ocular inflammation and ulceration at the acute stage. Due to the hidden nature of these ocular lesions and the concentration of effort toward life-threatening issues, current acute management has not devised a strategy to preclude blinding cicatricial complications. This review summarizes recent literature data, showing how sight-threatening corneal complications can progressively develop from cicatricial pathologies of lid margin, tarsus, and fornix at the chronic stage. It illustrates how such pathologies can be prevented with the early intervention of cryopreserved amniotic membrane transplantation to suppress inflammation and promote epithelial healing at the acute stage. Significant dry eye problems and photophobia can also be avoided with this intervention. This new therapeutic strategy can avert the catastrophic ophthalmic sequelae of this rare but devastating disease.