The Dry Eye Zone

Rebecca's Blog

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Abstract: Intralase and dry eye

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Typical. For FDA clinicals, of course we have to check both signs and symptoms because it is WELL KNOWN that there is a poor correlation between the two, but heaven forbid that anyone include assessment of symptoms in post refractive patients if they don't have to. JRS is probably the last ophthalmic publication I would expect to care about the distinction.
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PURPOSE: To evaluate changes in comeal sensitivity and tear function following myopic LASIK with thin femtosecond flaps.
J Refract Surg. 2008 Nov;24(9):897-902
Barequet IS, Hirsh A, Levinger S.


METHODS: A retrospective study was performed to compare corneal sensitivity (filament), tear breakup time, and anesthetized Schirmer test preoperatively and at 1 week and 2 and 6 months postoperatively.

RESULTS: Seventy-two eyes of 38 consecutive patients (20 women and 18 men) who underwent LASIK for myopia or myopic astigmatism with thin femtosecond flaps (IntraLase femtosecond laser system and Technolas 217 PlanoScan V2.9992 or wavefront-guided Zyoptix 3.1 excimer laser) were evaluated. Preoperative mean corneal sensitivity was 5.3+/-1.5 mm, which decreased to 4.6+/-1.7 mm at 1 week, increased to 5.0+/-1.3 mm at 2 months, and returned to baseline values at 6 months postoperatively. Mean Schirmer score was 13.7+/-5.7 mm preoperatively and 12.1+/-5.1, 13.1+/-4.8, and 13.0+/-5.1 mm at 1 week and 2 and 6 months postoperatively, respectively. Mean tear breakup time was 7.7+/-2.6 seconds preoperatively and 7.8+/-3.5, 9.2+/-4.6, and 8.8+/-4.5 seconds at 1 week and 2 and 6 months postoperatively, respectively. No significant increase in fluorescein staining was observed throughout follow-up.

CONCLUSIONS: Reductions in corneal sensitivity and tear function tests were minimal after myopic LASIK with thin femtosecond flaps. Despite the relatively narrow hinge, the thin, uniform femtosecond flap does not appear to have an adverse effect on corneal sensitivity and dry eye signs at 6 months postoperatively.

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