The Dry Eye Zone

Rebecca's Blog


Abstract: Cyclosporine & dry eye

Ho hum....

Ciclosporin use in dry eye disease patients.
Expert Opin Pharmacother. 2008 Dec;9(17):3121-8
Ridder WH 3rd.

BACKGROUND: Dry eye disease is one of the most commonly encountered conditions in eye care, and inflammation is a frequent finding. Ciclosporin has long been used systemically to decrease the deleterious effects of inflammation. Ciclosporin is a calcineurin inhibitor that acts by primarily blocking the action of T cells, decreasing the release of pro-inflammatory cytokines, and preventing the apoptosis of goblet cells.

OBJECTIVE: This article reviews the clinical trials and safety profile of an ophthalmic preparation of ciclosporin in the treatment of dry eye.

RESULTS/CONCLUSION: Clinical trials have demonstrated that ciclosporin minimizes the signs and symptoms of dry eye disease and is not associated with any significant systemic or ocular adverse reaction.