The Dry Eye Zone

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Abstract: Cetuximab and blepharitis

[Blepharitis related to Cetuximab treatment in an advanced colorectal cancer patient.]
Arch Soc Esp Oftalmol. 2008 Nov;83(11):665-8

CASE REPORT: A 52-year-old woman with advanced colorectal cancer was referred to us for treatment of Cetuximab-related ocular side-effects.
Ramírez-Soria MP, España-Gregori E, Aviñó-Martínez J, Pastor-Pascual F

DISCUSSION: Cetuximab is a monoclonal antibody that specifically blocks epidermal growth factor receptor activity. It has recently been approved to treat some tumors such as metastatic colorectal cancer and some ORL cancers. Tolerance to it seems to be better than that to the classic chemotherapeutic agents. However it has several side-effects. Cetuximab-related eyelid toxicity has been recently described, though the pathogenesis has not yet been clearly established (Arch Soc Esp Oftalmol 2008; 83: 665-668).