The Dry Eye Zone

Rebecca's Blog


Abstract: DIabetes and dry eye

Study of dry eye signs/symptoms in diabetics.

I get kind of suspicious when I see things like "A dry eye questionnaire" (without further identification) in the Methods. Seems to me that if it were a previously published, scientifically validated instrument they would say so.

Tear Film Function in Type 2 Diabetic Patients with Retinopathy.
Yu L, Chen X, Qin G, Xie H, Lv P
Ophthalmologica. 2008 Jun 18;222(4):284-291.

Purpose: To investigate whether diabetes mellitus is correlated with tear film dysfunction.
Methods: Tear film function tests including tear film breakup time (BUT), fluorescein staining, Schirmer I test, rose Bengal staining, total tear protein detection, tear sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and TMS-4 corneal topography were performed. A dry-eye questionnaire was used.
Results: Compared with the control group and nonproliferative diabetic retinopathy (NPDR) group, in the proliferative diabetic retinopathy (PDR) group, the BUT and the value of the Schirmer I test were reduced significantly (p < 0.01); corneal fluorescein staining scores, the positive rate of rose Bengal staining and the surface regularity index (SRI) and surface asymmetry index (SAI) were higher (p < 0.01); concentrations of lactoferrin and tear-specific prealbumin were lower (p < 0.01, p < 0.05, respectively). In diabetic patients, the SRI and SAI were positively correlated with fluorescein staining scores (r = 0.754, 0.480, p < 0.01, respectively), and the dry-eye symptoms were significantly related to an abnormal BUT and Schirmer I test (p < 0.01, respectively).
Conclusion: The declined tear film function is severer in the patients with PDR than in those with NPDR. Besides the traditional methods, tear SDS-PAGE and TMS corneal topographic indices contribute to the discovery of tear film dysfunction in diabetic patients. Copyright © 2008 S. Karger AG, Basel.