Kanon, just be aware that anti-depressents can actually cause and worsen dry eye. Now, obviously everyone is different, but if you are talking to your doctor about it make sure he's aware that your eyes are a big issue and to check through all known side effects of any drug he prescribes. I hope you find something soon that works for you!
I've a suspicion that the Effexor I was taking a few years ago was what pushed me over the line from moderate to severe DES. However, if anxiety/ depression were to become an issue again for me I'd certainly give anti-depressents another go. The relief they could bring to my state of mind could override any small affect on my DES.
The eye altering, alters all - William Blake