Of these 5 dysfunctional elements, the poor ocular sensitivity because of neurotrophic state is most unique and difficult to diagnose because these patients tend to have disproportionally fewer symptoms relative to their abnormal signs. The neurotrophic state results in the worst form of dry eye by dampening the V1 sensory input, thus invariably abolishing both reflexes controlling compositional and hydrodynamic factors. Because there are disproportionally fewer irritative symptoms, grading of symptoms using a questionnaire alone will surely fail to predict the severity of dry eye caused by such a dysfunctional element. It is thus advised to be suspicious of neurotrophic state whenever a patient presents with disproportionally fewer symptoms than signs.