PDA

View Full Version : Need advise from a biochemist !!! Re: Topical Cyclosporine



Ariel
19-Aug-2010, 12:51
As I know it to have worked for some of you I'm looking for a way to incorporate nighty use of topical cyclosporine into my every-day DE treatment. Some time ago I began using Cyclosporine eye drops with castor oil (aka Restasis) but doing it created some problems I had to overcome, one of which was the itching and burning. As the cause of it is the castor oil excipient I switched to a patented formulation of Cyclosporine that replaced the oil with a liposomal carrier.

The problem I'd be facing now if I choose to use topical Cyclosporine at night is that the compounding pharmacy from which I'm getting my Cyclosporine eye drops cannot produce ophthalmic ointment with liposomes. So if I were to use "Sandimmune" --which is the only ophthalmic ointment on the market with Cyclosporine as the main active ingredient-- I would have to deal with the itching and burning.

So I'm wondering if I could make an ophthalmic ointment for my own personal needs simply by mixing a dab of the Erythromycin ointment I use at night with two drops of the Cyclosporine with liposomes I use during the day. http://www.mayoclinic.com/health/drug-information/DR601925

Could this concoction combine the immunosuppressant, anti-inflammatory, and antibiotic benefits of both components? If the answer is "yes" one has to wonder if by adding two drops of "Azasite" to the mix I would also be giving it anti-bacterial properties. I suppose I could let my eyes answer these questions but perhaps I can get a biochemist to tell me what's most likely to happen.

All I've been using before going to bed up to now has been Erythromycin ointment or allergy drops. I only use the second every once in a while whenever I feel my eyes need them so I'm sort of "playing it by ear". It's not clear to me when and for how long allergy drops should be taken.